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Related Concept Videos

Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genetic Lingo01:11

Genetic Lingo

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Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pedigree Analysis01:35

Pedigree Analysis

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Related Experiment Video

Updated: Jul 3, 2026

VIGS-Mediated Forward Genetics Screening for Identification of Genes Involved in Nonhost Resistance
08:17

VIGS-Mediated Forward Genetics Screening for Identification of Genes Involved in Nonhost Resistance

Published on: August 23, 2013

[Genetics and disease resistance].

Gerald Reiner1

  • 1Klinikum Veterinärmedizin der Justus-Liebig-Universität Giessen. gerald.reiner@vetmed.uni-giessen.de

DTW. Deutsche Tierarztliche Wochenschrift
|August 5, 2008
PubMed
Summary

Understanding genetic disease resistance in livestock is key. Research highlights polygenic inheritance and environmental factors limiting gene discovery, but livestock offer unique insights for improving animal health and welfare.

Area of Science:

  • Animal Genetics
  • Immunology
  • Veterinary Science

Context:

  • Disease resistance is crucial in humans and animals, yet underlying genetic mechanisms are poorly understood.
  • Polygenic inheritance, lack of animal models, and environmental factors complicate the identification of disease resistance genes.
  • Ethical and practical challenges further impede research in specific species.

Purpose:

  • To review the genetic basis of disease resistance in livestock.
  • To discuss the practical implications of this research for animal health and welfare.
  • To present examples from own research activities.

Summary:

  • Genetic factors contribute to disease resistance across species, but complex inheritance patterns and environmental influences obscure specific gene functions.

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Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
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VIGS-Mediated Forward Genetics Screening for Identification of Genes Involved in Nonhost Resistance
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  • Livestock animals are valuable models due to their genetic diversity and metabolic similarities to humans, aiding disease resistance research.
  • Identifying genetic components of disease resistance in livestock can enhance production hygiene, economic efficiency, and animal well-being.

    • Impact:

    • Advances in understanding livestock disease resistance can improve animal welfare and reduce economic losses in agriculture.
    • This research provides a foundation for breeding programs aimed at enhancing disease resistance in livestock populations.
    • Insights gained from livestock models may inform human disease resistance research due to conserved biological pathways.