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Related Experiment Videos

Postoperative topical antimicrobial use.

Vaneeta M Sheth¹, Sarah Weitzul

¹Department of Dermatology and the Division of Dermatologic Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Dermatitis : Contact, Atopic, Occupational, Drug

|August 5, 2008

Summary

This summary is machine-generated.

Topical neomycin and bacitracin frequently cause allergic contact dermatitis in surgical patients. Avoid neomycin on closed wounds; use white petrolatum. For open wounds, choose topical antimicrobials without neomycin.

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Area of Science:

Dermatology
Wound Care
Allergology

Background:

Allergic contact dermatitis (ACD) from topical antimicrobials is a growing concern in postoperative wound management.
Neomycin and bacitracin are common causes of ACD in surgical settings.

Purpose of the Study:

To review common topical antimicrobials used postoperatively in North America and Europe.
To determine the incidence of ACD associated with these agents.
To provide guidelines for topical antimicrobial use on surgical wounds.

Main Methods:

Literature review of topical antimicrobial agents and their associated ACD rates.
Analysis of ACD incidence in general and postsurgical populations.
Comparison of ACD rates with postoperative infectious complication rates.

Main Results:

Neomycin (11%) and bacitracin (8%) were the most frequent causes of ACD, with a risk of co-reactivity.
Polymyxin B and mupirocin showed low allergenicity.
ACD rates (1.6-2.3%) were comparable to postoperative infection rates (1-2%).

Conclusions:

Avoid topical neomycin on closed postoperative wounds due to high ACD risk.
White petrolatum is a safe and effective alternative for closed surgical wounds.
For open wounds, topical antimicrobials lacking neomycin are recommended.