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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

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Related Experiment Video

Updated: Jul 3, 2026

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Primary nonfunction: timing retransplantation versus hemodynamic parameters and kidney function.

G Novelli1, M Rossi, L Poli

  • 1Dipartimento Paride Stefanini Unità di Chirurgia Generale e Trapianti d'Organo, La Sapienza Università di Roma, Rome, Italy. novelligilnardo@virgilio.it

Transplantation Proceedings
|August 5, 2008
PubMed
Summary
This summary is machine-generated.

The Molecular Adsorbent Recirculating System (MARS) improved hemodynamics and kidney function in acute liver failure patients with primary nonfunction. This treatment potentially enhances survival while awaiting liver retransplantation.

Related Experiment Videos

Last Updated: Jul 3, 2026

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Area of Science:

  • Hepatology
  • Nephrology
  • Critical Care Medicine

Background:

  • Acute liver failure (ALF) is characterized by hyperdynamic circulation.
  • Primary nonfunction (PNF) after liver transplantation presents significant hemodynamic challenges.

Purpose of the Study:

  • To evaluate the impact of the Molecular Adsorbent Recirculating System (MARS) on systemic hemodynamics.
  • To assess MARS-induced improvements in kidney function in patients with PNF.
  • To determine the effect of MARS on patient survival in ALF with PNF.

Main Methods:

  • MARS treatment was administered to 18 intensive care unit patients with PNF post-orthotopic liver transplantation (OLT) for a mean of 10 days.
  • Hemodynamic parameters (MAP, CI, SVRI, PVRI) and kidney function markers (serum creatinine, urea, urine volume) were monitored.
  • Continuous veno-venous access with a blood flow of 150-250 mL/min was utilized.

Main Results:

  • Significant improvements were observed in hemodynamic parameters, including mean arterial pressure (MAP) and resistance indices (PVRI/SVRI).
  • Kidney function showed significant enhancement, evidenced by reduced serum creatinine and urea levels, and increased urine output.
  • Survival rates were 61.1% (11 out of 18 patients) during the study period.

Conclusions:

  • The MARS device effectively improved hemodynamic status and renal function in ALF patients with PNF.
  • MARS treatment appears to contribute to improved patient survival while awaiting liver retransplantation.
  • The beneficial effects are likely due to the removal of vasoactive substances by the MARS system.