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Updated: Jul 3, 2026

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
Published on: July 3, 2013
Low duplicability and network fragility of cancer genes
Davide Rambaldi1, Federico M Giorgi, Fabrizio Capuani
1Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Abstract:
We identified genomic and network properties of approximately 600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein-protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore, other nodes of the human PIN with similar properties are rare and probably enriched in candidate cancer genes.
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