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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jul 3, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

[Juvenile dermatomyositis: 4 case studies].

T Marcil1, I Khoudri, M Meziane

  • 1Service de dermatologie-vénérologie, CHU Ibn-Sina, Souissi, 10100 Rabat, Maroc. tarikmarcil@hotmail.com

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|August 5, 2008
PubMed
Summary
This summary is machine-generated.

Juvenile dermatomyositis (JDM) is a rare autoimmune disease. Early diagnosis, particularly from skin symptoms, is crucial for better outcomes in JDM patients.

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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Area of Science:

  • Pediatric rheumatology
  • Autoimmune diseases
  • Rare diseases

Background:

  • Juvenile dermatomyositis (JDM) is a rare idiopathic inflammatory myopathy affecting children.
  • Historically, JDM had a poor prognosis before corticosteroid therapy.
  • Current treatments improve outcomes but carry significant long-term side effects.

Observation:

  • JDM diagnosis is challenging and frequently delayed due to its rarity.
  • Delayed diagnosis and treatment are linked to poorer patient prognosis.
  • Characteristic skin manifestations often present early, aiding diagnosis.

Findings:

  • This study presents a 10-year clinical experience with juvenile dermatomyositis.
  • Analysis focuses on diagnostic challenges and prognostic factors.
  • The role of early cutaneous findings in JDM diagnosis is highlighted.

Implications:

  • Emphasizes the need for increased awareness of JDM among clinicians.
  • Highlights the importance of recognizing early cutaneous signs for timely intervention.
  • Suggests strategies to improve diagnostic pathways and patient outcomes in JDM.