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Updated: Jul 3, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
[Beyond dyssynchrony: what are the factors determining the response to cardiac resynchronization therapy?]
Donato Mele1, Tiziano Toselli, Alessandro Dal Monte
1UO di Cardiologia, Azienda Ospedaliera Universitaria, Ferrara. donatomele@libero.it
Abstract:
Although cardiac resynchronization therapy is currently used for treatment of refractory heart failure in patients with low ejection fraction and cardiac dyssynchrony, there is a substantial number of non-responders. This indicates that, in addition to cardiac dyssynchrony, there are other factors affecting response to cardiac resynchronization therapy. Pre-implant identification of these factors appears of crucial importance in order to finalize the resynchronization treatment to those patients who have the highest probability of a positive response. In this review the main non-dyssynchrony determinants of response to cardiac resynchronization therapy are presented and discussed.
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