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Updated: Jul 3, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Network atrophy in temporal lobe epilepsy: a voxel-based morphometry study.

F Riederer1, R Lanzenberger, M Kaya

  • 1Universitätsklinik für Neurologie Wien, Klinische Abteilung für Epilepsieforschung, Vienna, Australia.

Neurology
|August 6, 2008
PubMed
Summary
This summary is machine-generated.

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Mesial temporal lobe epilepsy (mTLE) and cryptogenic TLE (cTLE) involve distinct neuronal network damage, with greater gray matter volume loss in left-sided seizure foci. Cingulum atrophy is common in left-sided epilepsy.

Area of Science:

  • Neuroscience
  • Neurology
  • Epilepsy Research

Background:

  • Recent evidence indicates temporal lobe epilepsy involves neuronal networks, not isolated brain structures.
  • Voxel-based morphometry (VBM) studies show extrahippocampal gray matter abnormalities in mesial temporal lobe epilepsy (mTLE) with hippocampal sclerosis.
  • VBM studies have not consistently reported gray matter abnormalities in cryptogenic or MRI-negative TLE (cTLE).

Purpose of the Study:

  • To detect gray matter abnormalities in patients with mTLE and cTLE compared to healthy controls using optimized VBM.
  • To investigate differences in neuronal network damage between mTLE and cTLE.
  • To explore the impact of seizure focus laterality on gray matter volume reduction.

Main Methods:

  • Optimized VBM with modulation was employed to analyze gray matter volume.

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  • The study included 22 patients with mTLE, 17 patients with cTLE, and 12 healthy controls.
  • Patient groups were analyzed based on seizure focus laterality (right/left).

    • Main Results:

    • mTLE patients showed decreased gray matter volume (GMV) in the ipsilateral thalamus.
    • Left-sided mTLE exhibited more widespread GMV decrease, including the parahippocampal gyrus, superior temporal gyrus, frontal regions, cerebellum, and right cingulum.
    • cTLE patients displayed decreased GMV in frontal and orbitofrontal cortex, cerebellum, temporal neocortical regions, and right parahippocampal cortex, with more extensive loss in left-sided foci.

    Conclusions:

    • Distinct neuronal network damage is evident in mTLE and cTLE, being more pronounced in left-sided seizure foci.
    • Atrophy of the cingulum is a shared characteristic of left-sided mTLE and cTLE.
    • Findings suggest network-based pathology in temporal lobe epilepsy that varies with etiology and seizure focus laterality.