Pathogenicity of fowl enteroviruses
M Decaesstecker1, G Charlier, J Peeters
1National Institute for Veterinary Research, Brussels, Belgium.
Avian Pathology : Journal of the W.V.P.A
|October 1, 1989
Summary
Avian nephritis virus and related enteroviruses show varied pathogenicity in chickens. Some fowl enteroviruses cause intestinal lesions and organ damage, while others primarily affect the kidneys.
Area of Science:
- Veterinary Virology
- Avian Pathology
Background:
- Fowl enteroviruses are a significant concern in poultry health.
- Understanding the pathogenicity of different enterovirus strains is crucial for disease control.
Purpose of the Study:
- To investigate and compare the pathogenicity of avian nephritis virus (ANV) and related enteroviruses in specific pathogen-free chickens.
- To determine the tropism and pathological effects of different fowl enterovirus strains.
Main Methods:
- Oral inoculation of one-day-old specific pathogen-free chickens with ANV, McNulty's entero-like particles, entero PV2, and entero 3.
- Immunofluorescence and transmission electron microscopy to detect viral replication.
- Histopathological examination of intestinal, pancreatic, proventricular, and kidney tissues at various post-inoculation days.
Main Results:
- All tested viruses replicated in enterocyte cytoplasm.
- Intestinal lesions were observed in chickens infected with McNulty's entero-like particles, entero PV2, and entero 3, peaking at 7 days post-inoculation.
- Variable lesions in pancreas, proventriculus, or kidneys were noted 14 days post-inoculation; ANV primarily induced kidney lesions.
Conclusions:
- Fowl enteroviruses within the same species can exhibit different tissue tropisms.
- These tropisms lead to diverse clinical signs and pathologies, including nephritis and malabsorption syndrome.
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