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Updated: Jul 3, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Expedient total syntheses of WIN 64745 and WIN 64821
Carlos Pérez-Balado1, Angel R de Lera
1Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, As Lagoas-Marcosende, 36310 Vigo, Spain.
Abstract:
Bispyrrolidinoindoline diketopiperazine alkaloids were synthesized from a common intermediate in seven steps from commercially available amino acids. This versatile synthetic strategy has led to the accomplishment of the first total synthesis of heterodimeric WIN 64745 and a novel approach to homodimeric WIN 64821.
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