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Updated: Jul 3, 2026

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Enantioselective synthesis of a mealybug pheromone with an irregular monoterpenoid skeleton
Kosuke Hashimoto1, Akira Morita, Shigefumi Kuwahara
1Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.
The Journal of Organic Chemistry
|August 6, 2008
Abstract:
The first enantioselective synthesis of a mealybug sex pheromone with an unprecedented monoterpenoid skeleton has been accomplished by using a highly diastereoselective conjugate addition of an organocopper reagent to a gamma-alkyl-alpha,beta-unsaturated ester intermediate as the key step.

