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Updated: Jul 3, 2026
07:02
Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
Published on: February 10, 2026
A new approach to acute renal failure
1Michael Reese Hospital and Mercy Hospital, Chicago, IL, USA. shelman100@aol.com
Comprehensive Therapy
|August 7, 2008
Summary
Pre-renal failure terminology is imprecise for hemodynamic changes causing kidney injury. New terms, normotensive ischemic acute renal failure and prerenal success, offer clearer descriptions of kidney dysfunction.
Area of Science:
- Nephrology
- Renal Medicine
- Acute Kidney Injury
Background:
- The term "pre-renal failure" inadequately describes hemodynamic alterations leading to acute kidney injury.
- Existing terminology fails to capture nuances of conditions with low-normal blood pressure or volume and elevated serum creatinine.
Purpose of the Study:
- To review and clarify terminology for hemodynamic changes causing acute kidney injury.
- To introduce and define "normotensive ischemic acute renal failure" and "prerenal success" as more precise descriptors.
Main Methods:
- Literature review of hemodynamic changes and acute kidney injury.
- Conceptual analysis of existing and proposed terminology.
Main Results:
- "Pre-renal failure" is an imprecise term for complex hemodynamic kidney injury.
- "Normotensive ischemic acute renal failure" and "prerenal success" provide more accurate descriptions.
Conclusions:
- Adoption of precise terminology is crucial for understanding and managing acute kidney injury.
- Clarified terms enhance diagnostic accuracy and therapeutic strategies in renal medicine.
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