A rare case of recessive dystrophic epidermolysis bullosa and verruciform xanthoma
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Updated: Jul 3, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
S D Orpin1, I C Scott, R Rajaratnam
1Department of Dermatology, Solihull Hospital, Solihull, West Midlands, UK. s.orpin@nhs.net
Abstract:
A 33-year-old man with recessive dystrophic epidermolysis bullosa presented with a 3-month history of an enlarging mass within scarring on the posterior aspect of the right shoulder. The clinical appearance of the mass with an almost cobbled, verrucous surface, and its rapid evolution suggested the development of a squamous cell carcinoma (SCC) in a chronically scarred site. Histopathological examination of a biopsy taken from the lesion subsequently revealed it to be a verruciform xanthoma. This case shows that benign phenomena can mimic SCC and underlines the need for a biopsy to be taken promptly.
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