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Updated: Jul 3, 2026

Growth Assays to Assess Polyglutamine Toxicity in Yeast
Published on: March 5, 2012
[The advances in research on phosphorylation of polyglutamine disease]
Ya-fang Zhou1, Hong Jiang, Jian-guang Tang
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 People's Republic of China.
Abstract:
Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of a glutamine repeat in responsible gene products. To date, the pathogenesis of polyQ diseases is still not very clear, but many researches suggest that phosphorylation of mutant proteins plays a critical role on the process of Huntington's disease, dentatorubral-pallidoluysian atrophy, spinal bulbar muscular atrophy, spinocerebellar ataxia1 and spinocerebellar ataxia 3/Machado-Joseph disease.
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