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Grid cells in mice.

Marianne Fyhn1, Torkel Hafting, Menno P Witter

  • 1Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway.

Hippocampus
|August 8, 2008
PubMed
Summary
This summary is machine-generated.

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Grid cells, crucial for spatial navigation, were discovered in the mouse medial entorhinal cortex (EC). This finding opens doors for genetic studies on the entorhinal-hippocampal network and spatial coding mechanisms.

Area of Science:

  • Neuroscience
  • Spatial Cognition
  • Computational Neuroscience

Background:

  • The medial entorhinal cortex (EC) is vital for self-location representation.
  • Grid cells within the EC exhibit regular firing patterns, forming a spatial code.
  • Neuronal mechanisms underlying grid cell function remain largely unknown.

Purpose of the Study:

  • To investigate the presence of grid cell activity in mice.
  • To establish a foundation for genetic manipulation studies in the entorhinal-hippocampal network.
  • To compare mouse grid cell properties with those in rats.

Main Methods:

  • Electrophysiological recordings from principal neurons in the superficial layers of the mouse medial EC.
  • Analysis of neuronal firing fields to identify grid cell properties.

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  • Comparison of grid spacing, orientation, and co-localization with other cell types to rat data.

    • Main Results:

    • Stable grid cell activity was observed in the mouse medial EC, mirroring rat findings.
    • Neighboring grid cells shared spacing and orientation but differed in spatial phase.
    • Grid spacing increased with distance from the dorsal EC border; dorsal grid spacing was comparable to rats.
    • Grid cells were found alongside head-direction and conjunctive cells, similar to rats.

    Conclusions:

    • Grid cells are present in mice, validating their use in genetic studies.
    • Mouse grid cell properties are conserved but do not scale proportionally with body size compared to rats.
    • This discovery facilitates future transgenic investigations into the entorhinal-hippocampal network and spatial coding.