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Cholelithiasis is a risk factor for colorectal adenoma
Yutaka Yamaji1, Makoto Okamoto, Haruhiko Yoshida
1Department of Gastroenterology, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Jaqan.
The American Journal of Gastroenterology
|August 8, 2008
Summary
Gallstones (cholelithiasis) significantly increase the risk of developing colorectal adenomas. This association remained even after adjusting for other lifestyle and demographic factors, highlighting gallstones as an independent risk factor.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Postcholecystectomy patients face a moderate risk of colorectal cancer.
- The relationship between gallstones (cholelithiasis) and colorectal adenoma requires further investigation.
Purpose of the Study:
- To examine the association between cholelithiasis and colorectal adenoma in asymptomatic Japanese individuals.
- To determine if gallstones or prior cholecystectomy increase colorectal adenoma risk.
Main Methods:
- Analysis of a subgroup from a prospective colonoscopy screening survey.
- Inclusion of subjects who underwent colonoscopy, ultrasonography, and completed lifestyle questionnaires.
- Comparison of colorectal adenoma prevalence between subjects with and without gallstones or cholecystectomy.
Main Results:
- Cholelithiasis was detected in 206 of 4,458 subjects.
- Colorectal adenoma prevalence was significantly higher in subjects with cholelithiasis (29.6%) compared to those with normal gallbladders (17.7%, P < 0.001).
- Cholelithiasis was an independent risk factor for colorectal adenoma (adjusted OR 1.57), particularly for multiple and left-sided adenomas.
Conclusions:
- Cholelithiasis is confirmed as a significant risk factor for colorectal adenoma.
- No significantly increased risk of colorectal adenoma was observed in patients who had undergone cholecystectomy.
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