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Updated: Jul 3, 2026

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Dermatofibrosarcoma protuberans: wide local excision vs. Mohs micrographic surgery.

A Paradisi¹, D Abeni, A Rusciani

¹Department of Dermatology, Catholic University of the Sacred Heart, Rome, Italy. aparad@tin.it

Cancer Treatment Reviews

|August 8, 2008

Summary

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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Mohs micrographic surgery (MMS) shows significantly lower recurrence rates for dermatofibrosarcoma protuberans (DFSP) compared to wide local excision (WLE). Pooled data confirm MMS as a more effective treatment for DFSP, particularly for head and neck tumors.

Area of Science:

Dermatologic Surgery
Surgical Oncology
Cutaneous Oncology

Background:

Dermatofibrosarcoma protuberans (DFSP) is a rare skin tumor with a high propensity for local recurrence.
The optimal surgical management for DFSP, comparing Mohs micrographic surgery (MMS) and wide local excision (WLE), remains a subject of debate.
Preliminary studies suggest potentially better outcomes with MMS for DFSP treatment.

Purpose of the Study:

To compare the recurrence rates of dermatofibrosarcoma protuberans (DFSP) treated with Mohs micrographic surgery (MMS) versus wide local excision (WLE).
To pool institutional data with existing literature to provide more robust estimates of treatment efficacy for DFSP.
To inform clinical decision-making regarding the most appropriate surgical approach for DFSP.

Main Methods:

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Last Updated: Jul 3, 2026

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Retrospective review of 79 patients with DFSP treated between 1990-2005 (38 with WLE, 41 with MMS).
Systematic search of the PubMed database for case series of DFSP treated with WLE or MMS.
Meta-analysis of recurrence proportions from both the institutional cohort and literature data.

Main Results:

In the institutional cohort, 13.2% of WLE patients experienced recurrence versus 0% of MMS patients.
Pooled analysis revealed significantly lower recurrence rates for MMS (1.3%) compared to WLE (20.7%).
The relative risk of recurrence for WLE versus MMS was 15.9, indicating a substantial increased risk with WLE.

Conclusions:

Mohs micrographic surgery (MMS) is associated with significantly lower recurrence rates for dermatofibrosarcoma protuberans (DFSP) compared to wide local excision (WLE).
Pooled data strongly support the superiority of MMS in managing DFSP, particularly for primary tumors and those located on the head and neck.
These findings provide valuable evidence to guide surgical treatment choices for DFSP, favoring MMS for improved local control.