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Updated: Jul 3, 2026
08:54
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
Published on: April 27, 2015
Liver preservation: is there anything new yet?
James V Guarrera1, Niaz A Karim
1Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032 USA. jjg46@columbia.edu
Current Opinion in Organ Transplantation
|August 8, 2008
Summary
Recent advancements in liver preservation show promise, with machine perfusion and new solutions improving outcomes for liver transplantation. Future strategies will integrate these innovations to minimize organ injury and enhance patient results.
Area of Science:
- Hepatology
- Transplantation Medicine
- Organ Preservation
Background:
- Liver preservation is critical for successful transplantation.
- Current methods face challenges in preventing organ damage and complications.
Purpose of the Study:
- To review recent developments in liver preservation techniques.
- To update on advancements in solutions and machine perfusion.
Main Methods:
- Comprehensive literature review.
- Analysis of recent clinical trials and preclinical studies.
Main Results:
- Preservation solutions show clinical equivalence, but biliary complications remain debated.
- New agents targeting steatosis and DCD (donors after cardiac death) pathophysiology show promise.
- Hypothermic machine perfusion demonstrates safety and improved efficacy in early human trials.
Conclusions:
- Liver preservation is rapidly advancing.
- A combined strategy of pharmacologic agents and hypothermic machine perfusion is expected to optimize outcomes.
- Increased translation of innovations into clinical trials is needed.
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