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Related Experiment Videos

Drug delivery to the brain using polymers.

A Domb1, M Maniar, S Bogdansky

  • 1Nova Pharmaceutical Corporation, Baltimore, MD 21224.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1991
PubMed
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Drug delivery to the brain faces challenges at the blood-brain barrier (BBB). This review focuses on polymer-based implants for sustained and controlled central nervous system (CNS) drug delivery.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biomaterials Science

Background:

  • Drug delivery to the central nervous system (CNS) is hindered by the blood-brain barrier (BBB).
  • Effective CNS drug delivery requires brain access, localized effects, stability, and controlled dosage.
  • Current strategies include systemic administration and direct brain delivery methods.

Purpose of the Study:

  • To review polymer-based implantable systems for drug delivery to the brain.
  • To cover nondegradable and biodegradable polymer implants from concept to clinical application.

Main Methods:

  • Review of existing literature on polymer-based drug delivery systems for CNS applications.
  • Focus on implantable systems, including both nondegradable and biodegradable polymers.

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Main Results:

  • Both systemic and direct drug delivery approaches have advantages and disadvantages.
  • Polymer-based implants offer a promising strategy for overcoming BBB challenges.
  • The review encompasses a range of polymer implant technologies.

Conclusions:

  • Polymer-based implantable systems represent a significant advancement in CNS drug delivery.
  • These systems provide a means to achieve localized, sustained, and controlled drug release.
  • Further development and clinical translation of polymer implants are crucial for treating neurological disorders.