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08:15
Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids
Published on: November 15, 2019
The nutritional modulation of the evolving intestine
Roberto Berni Canani1, Annalisa Passariello, Vittoria Buccigrossi
1Department of Pediatrics, University Federico II of Naples, Naples, Italy. berni@unina.it
Journal of Clinical Gastroenterology
|August 8, 2008
Summary
Nutrition significantly impacts the developing human gut, influencing its ecosystem and potentially affecting inherited gastrointestinal disorders through epigenetic mechanisms. This research explores nutritional modulation of intestinal development.
Area of Science:
- Gastroenterology and Nutritional Science
- Human Gut Microbiome Research
- Epigenetics and Developmental Biology
Background:
- Nutrition is a critical factor in the development and function of the human gut ecosystem.
- Its regulatory role is vital during early life and continues throughout adulthood.
- Emerging evidence suggests nutrition influences inherited gastrointestinal disorders via epigenetic pathways.
Purpose of the Study:
- To review the primary components and mechanisms of nutritional modulation on intestinal development.
- To highlight the role of nutrition in shaping the gut ecosystem.
- To explore the connection between nutrition, epigenetics, and gastrointestinal health.
Main Methods:
- Literature review of current research on nutritional modulation of the gut.
- Analysis of studies investigating epigenetic mechanisms in intestinal development.
- Synthesis of data on the impact of nutrition on gut enzymes, hormones, transporters, and immunity.
Main Results:
- Nutrition profoundly influences the composition and function of the intestinal ecosystem.
- Epigenetic mechanisms mediate nutritional effects on key gastrointestinal components.
- Nutritional interventions show potential for managing certain inherited gastrointestinal conditions.
Conclusions:
- Nutritional modulation is a key factor in intestinal development and function.
- Epigenetic pathways are crucial mediators of nutrition's impact on the gut.
- Further research into nutritional interventions for gastrointestinal disorders is warranted.
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