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Updated: Jul 3, 2026

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants
Published on: October 28, 2022
Noninvasive devices targeting the mechanics of osteoarthritis
K Douglas Gross1, Howard J Hillstrom
1Clinical Epi Res & Train Un, Boston University School of Medicine, 715 Albany Street, X-200, Boston, MA 02118, USA. grossd@bu.edu
Abstract:
The goal of many noninvasive devices for knee osteoarthritis (OA) is to alter joint biomechanics and thereby limit regional exposure to damaging and provocative mechanical stresses. Optimal prescription of most noninvasive devices first requires the specification of which mechanical stresses should be reduced, and in which knee region. This article introduces several types of devices currently used in the treatment of knee OA. Each section begins with a short presentation of the device's biomechanical effects and considers evidence of clinical efficacy. Where possible, the authors conclude each section by offering their subjective insights and clinical impressions.
