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Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

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Related Experiment Video

Updated: Jul 3, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

Post-training progesterone dose-dependently enhances object, but not spatial, memory consolidation.

Lauren L Harburger¹, Angela S Pechenino, Altaf Saadi

¹Department of Psychology, 2 Hillhouse Avenue, Yale University, New Haven, CT 06520, USA. lauren.harburger@yu.edu

Behavioural Brain Research

|August 9, 2008

Summary

Progesterone enhanced object memory consolidation in young female mice but did not improve spatial memory. This suggests object memory is more sensitive to progesterone

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Last Updated: Jul 3, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

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Published on: August 30, 2017

Place and Response Learning in the Open-field Tower Maze

Place and Response Learning in the Open-field Tower Maze

Published on: October 28, 2015

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Area of Science:

Neuroscience
Endocrinology
Behavioral Science

Background:

Progesterone is a key hormone influencing cognitive functions.
Its role in memory consolidation, particularly in young female mammals, requires further elucidation.
Ovariectomized mice provide a model to study hormone-specific effects on memory.

Purpose of the Study:

To investigate the modulatory effects of progesterone on object and spatial memory consolidation.
To determine if progesterone enhances memory performance in young ovariectomized mice.
To compare the sensitivity of object versus spatial memory to progesterone treatment.

Main Methods:

Young ovariectomized C57BL/6 mice were used.
Object memory was assessed using an object recognition task with 24- and 48-h delays.
Spatial memory was evaluated via a 2-day Morris water maze task with 24- or 48-h retention intervals.
Mice received post-training intraperitoneal injections of vehicle or varying doses of water-soluble progesterone (5, 10, 20 mg/kg).

Main Results:

Post-training administration of 10 and 20 mg/kg progesterone significantly enhanced object recognition memory.
Progesterone treatment did not yield significant improvements in spatial memory performance in the Morris water maze.
These effects were observed in the absence of circulating progesterone during testing.

Conclusions:

Object memory consolidation in young female mice is more responsive to progesterone than spatial memory consolidation.
The findings highlight a potential differential impact of progesterone on distinct memory systems.
These results have implications for developing progesterone-based therapies for memory decline.