Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Conditional gp130 deficient mouse mutants.

Nicolas Fasnacht¹, Werner Müller

¹Helmholtz-Center for Infection Research, Braunschweig, Germany.

Seminars in Cell & Developmental Biology

|August 9, 2008

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SUNRAY-01 trial protocol: an innovative study design of olomorasib and pembrolizumab with or without chemotherapy in <i>KRAS</i> G12C NSCLC.

Future oncology (London, England)·2026

Same author

Reflux symptoms in patients with mini gastric bypass-one anastomotic bypass (MGB-OAGB) after failed laparoscopic gastric banding (LAGB) - Long-term follow-up and therapeutic options.

American journal of surgery·2026

Same author

CSF1R<sup>+</sup> myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma.

Cancer cell·2025

Same author

Author Correction: IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease.

Nature communications·2024

Same author

IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease.

Nature communications·2024

Same author

Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging.

Nature methods·2023

The gp130 receptor chain regulates key cytokines involved in inflammation and immunity. Conditional gp130 mutants in mice help dissect this complex cellular cytokine network, overcoming redundancy issues.

Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

The glycoprotein 130 (gp130) receptor chain is central to the activity of numerous cytokines, including IL-6 and LIF.
These cytokines are crucial for diverse biological processes such as inflammation, immune responses, and cell survival.
Previous studies using single cytokine knockout mice were limited by functional redundancy within the IL-6 family.

Purpose of the Study:

To investigate the intricate roles of the gp130 cytokine network.
To overcome the limitations of redundancy in studying IL-6 family cytokines.
To summarize findings from conditional gp130 receptor chain mutants in mice.

Main Methods:

Generation of conditional gp130 receptor chain knockout mouse models.

More Related Videos

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Published on: November 19, 2011

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Published on: March 16, 2022

Related Experiment Videos

Last Updated: Jul 3, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Published on: November 19, 2011

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Published on: March 16, 2022

Cell type-specific inactivation of the gp130 receptor chain.

Analysis of experimental results from these conditional mutants.

Main Results:

Conditional gp130 mutants enable the dissection of cellular cytokine networks.
This approach provides a clearer understanding of cytokine functions despite redundancy.
Summarizes published experimental data from these conditional mouse models.

Conclusions:

Conditional inactivation of gp130 is a powerful strategy to study cytokine function.
This research clarifies the roles of gp130-mediated signaling in various biological processes.
The findings contribute to a deeper understanding of the cellular cytokine network.