Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) Study.

JAMA internal medicine·2015
Same author

Statins and brain integrity in older adults: secondary analysis of the Health ABC study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2015
Same author

Resting heart rate and risk of incident heart failure: three prospective cohort studies and a systematic meta-analysis.

Journal of the American Heart Association·2015
Same author

The Pittsburgh Fatigability scale for older adults: development and validation.

Journal of the American Geriatrics Society·2015
Same author

Visual impairment and incident mobility limitations: the health, aging and body composition study.

Journal of the American Geriatrics Society·2014
Same author

Statin use and decline in gait speed in community-dwelling older adults.

Journal of the American Geriatrics Society·2014
Same journal

Design and procedures for the greenness, cognitive performance and vascular outcomes in the northern Manhattan study (NOMAS-greenness).

American journal of epidemiology·2026
Same journal

Correction to: Home dampness and molds and occurrence of respiratory tract infections in the first 27 years of life: the Espoo Cohort Study.

American journal of epidemiology·2026
Same journal

A SIMPLE AND POWERFUL TEST OF VACCINE WANING.

American journal of epidemiology·2026
Same journal

Association Between maternal body mass index, offspring growth and pubertal timing: results from a longitudinal birth cohort study.

American journal of epidemiology·2026
Same journal

Correction to: Developing a novel algorithm to identify incident and prevalent dementia in Medicare claims-the ARIC Study.

American journal of epidemiology·2026
Same journal

RE: advancing observational research on arts and health: theory-informed approaches using the RADIANCE framework.

American journal of epidemiology·2026
See all related articles

Related Experiment Videos

Inflammatory markers and longitudinal lung function decline in the elderly.

Rui Jiang1, Gregory L Burke, Paul L Enright

  • 1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

American Journal of Epidemiology
|August 9, 2008
PubMed
Summary
This summary is machine-generated.

Higher fibrinogen levels, but not C-reactive protein (CRP), predict accelerated lung function decline in older adults. This study investigated inflammatory markers and their impact on respiratory health over time.

Related Experiment Videos

Area of Science:

  • Gerontology
  • Pulmonology
  • Biomarkers

Background:

  • Longitudinal data on inflammatory markers like fibrinogen and C-reactive protein (CRP) and their association with lung function decline are limited.
  • Aging populations necessitate understanding factors contributing to respiratory health deterioration.

Purpose of the Study:

  • To investigate the association between elevated baseline levels of fibrinogen and CRP and the rate of lung function decline in elderly individuals.
  • To determine if these inflammatory markers independently predict longitudinal changes in lung function.

Main Methods:

  • The Cardiovascular Health Study enrolled 5,790 participants aged 65+.
  • Fibrinogen and CRP levels were measured, and spirometry (FEV(1)/FVC) was conducted over a 16-year period.
  • Mixed-effects models were used to analyze the relationship between inflammatory markers and lung function decline.

Main Results:

  • Higher baseline fibrinogen levels were significantly associated with a faster decline in the forced expiratory volume in 1 second/forced vital capacity (FEV(1)/FVC) ratio.
  • No significant association was found between baseline C-reactive protein (CRP) levels and the rate of FEV(1)/FVC decline.
  • Analyses for FEV(1) and FVC alone showed unexpected inverse associations with mortality, complicating interpretation.

Conclusions:

  • Elevated fibrinogen independently predicts a greater decline in the FEV(1)/FVC ratio among the elderly.
  • C-reactive protein (CRP) did not show a significant association with longitudinal lung function decline in this cohort.
  • Fibrinogen may serve as a potential biomarker for predicting accelerated lung function decline in aging populations.