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Published on: June 2, 2014
Migraine, vascular risk, and cardiovascular events in women: prospective cohort study
Tobias Kurth1, Markus Schürks, Giancarlo Logroscino
1Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. tkurth@rics.bwh.harvard.edu
Objectives:
To evaluate whether the association between migraine with aura and increased risk of cardiovascular disease is modified by vascular risk groups as measured by the Framingham risk score for coronary heart disease.
Design:
Prospective cohort study.
Setting:
Women's health study, United States.
Participants:
27 519 women who were free from cardiovascular disease at baseline with available information on the Framingham risk score and migraine status.
Main Outcome Measures:
Time to major cardiovascular disease event (non-fatal myocardial infarction, non-fatal ischaemic stroke, death from ischaemic cardiovascular disease), myocardial infarction, and ischaemic stroke.
Results:
At baseline, 3577 (13.0%) women reported active migraine, of whom 1418 (39.6%) reported migraine with aura. During 11.9 years of follow-up, there were 697 cardiovascular disease events. We stratified participants based on 10 year risk of coronary heart disease estimated from the Framingham risk score (
Conclusion:
The association between migraine with aura and cardiovascular disease varies by vascular risk status. Information on history of migraine and vascular risk status might help to identify women at increased risk for specific future cardiovascular disease events.
Trial Registration:
Clinical trials NCT00000479.
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