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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Reactions02:06

Allergic Reactions

Overview
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

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Related Experiment Video

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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
08:12

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Allergy as a possible predisposing factor for hypodontia.

Tetsutaro Yamaguchi1, Yoko Tomoyasu, Toshio Nakadate

  • 1Departments of Orthodontics, Showa University, Tokyo, Japan. tetsu@senzoku.showa-u.ac.jp

European Journal of Orthodontics
|August 9, 2008
PubMed
Summary

This study found that general health issues, particularly allergies, are linked to hypodontia (congenital absence of teeth) in Japanese orthodontic patients. These findings suggest a potential environmental influence on tooth development.

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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
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Published on: November 1, 2014

Area of Science:

  • Dentistry
  • Genetics
  • Public Health

Background:

  • Hypodontia, the congenital absence of teeth, is a common dental anomaly.
  • Its etiology is multifactorial, involving genetic and environmental factors.
  • Understanding predisposing factors is crucial for early diagnosis and management.

Purpose of the Study:

  • To investigate the association between general health problems and hypodontia.
  • To identify potential predisposing factors for hypodontia in a Japanese orthodontic population.

Main Methods:

  • Retrospective study of 3683 Japanese orthodontic patients (13-42 years).
  • Diagnosis of hypodontia using dental pantomograms (DPTs).
  • Health histories collected via dentist-administered questionnaires; statistical analysis using the Mantel-Haenszel test.

Main Results:

  • Overall hypodontia prevalence was 5.8%, with an average of 1.7 missing teeth per patient.
  • Significant association found between hypodontia and allergy (P < 0.01).
  • Other systemic complications like asthma, atopy, and enlarged adenoids showed a high prevalence but no significant relationship.

Conclusions:

  • General health problems, especially allergies, appear to be predisposing factors for hypodontia.
  • Environmental factors, particularly allergies, may play a role in the etiology of hypodontia.
  • Further research is needed to fully elucidate the environmental causes of hypodontia.