Related Experiment Video

Updated: Jul 3, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

[Treatment of advanced penile cancer. Do we need new methods for chemotherapy?]

C Protzel1, H-J Klebingat, O W Hakenberg

  • 1Klinik und Poliklinik für Urologie, Universität Rostock, Rostock, Deutschland.

Der Urologe. Ausg. A
|August 9, 2008
PubMed

Insights

Advanced penile cancer has high mortality and limited treatment options. New research is needed to define effective systemic therapies for metastatic disease, as current methods are toxic and poorly effective.

Area of Science:

  • Oncology
  • Urologic Oncology
  • Cancer Research

Context:

  • Penile cancer is a rare but aggressive squamous cell neoplasia.
  • Advanced stages are associated with very high mortality rates.
  • Current systemic treatment options for advanced penile carcinoma are limited, toxic, and often ineffective.

Purpose:

  • To highlight the critical need for improved systemic treatment strategies in advanced penile cancer.
  • To underscore the limitations of existing therapeutic regimens and guidelines.
  • To emphasize the necessity for large-scale studies and novel chemotherapeutic approaches.

Summary:

  • Systemic treatment for advanced penile carcinoma is poorly defined due to limited data and small patient cohorts.
  • Established chemotherapy regimens exhibit high toxicity and low efficacy.
  • Anecdotal evidence suggests potential promise for newer chemotherapeutic agents, warranting further investigation.

Impact:

  • This review calls for urgent development of more effective and less toxic treatments for advanced penile cancer.
  • It highlights the need for robust clinical trials to establish evidence-based guidelines.
  • Improved therapeutic strategies could significantly enhance survival and quality of life for patients with metastatic penile carcinoma.

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.