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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Churg-Strauss syndrome].

François Lhote1, Pascal Cohen, Philippe Guilpain

  • 1Service de médecine interne, Centre hospitalier de Saint-Denis, 93200 Saint-Denis. francois.lhote@ch-stdenis.fr

La Revue Du Praticien
|August 12, 2008
PubMed
Summary

Churg-Strauss syndrome, a rare vasculitis linked to asthma and eosinophilia, requires prompt diagnosis and treatment with corticosteroids and immunosuppressants for remission. While survival rates are improving, long-term asthma management remains crucial for most patients.

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Published on: September 20, 2018

Area of Science:

  • Rheumatology
  • Immunology
  • Pulmonology

Context:

  • Churg-Strauss syndrome (CSS) is a rare systemic small-vessel vasculitis characterized by asthma and hypereosinophilia.
  • It presents with diverse systemic manifestations including purpura, mononeuritis multiplex, and potentially severe organ damage.
  • Anti-neutrophil cytoplasmic antibodies with a perinuclear fluorescence pattern (pANCA), particularly anti-myeloperoxidase (anti-MPO), are found in a subset of patients.

Purpose:

  • To outline the key diagnostic features of Churg-Strauss syndrome, emphasizing clinical presentation in patients with late-onset asthma.
  • To highlight the significant morbidity and mortality associated with cardiac involvement in CSS.
  • To discuss current treatment strategies and prognostic factors influencing patient outcomes.

Summary:

  • CSS diagnosis relies on clinical features, including constitutional symptoms, marked eosinophilia, and systemic vasculitic manifestations in asthmatic patients.
  • Cardiac involvement is a primary driver of mortality, necessitating vigilant monitoring and management.
  • Treatment involves corticosteroids and immunosuppressive agents, guided by prognostic scores, achieving high remission rates but frequent relapses.

Impact:

  • Improved understanding of CSS diagnostic criteria aids in earlier recognition and intervention.
  • Focus on cardiac manifestations can reduce CSS-specific mortality.
  • Effective treatment strategies contribute to high remission rates and improved long-term survival, though chronic asthma management is essential.