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Diffusional channeling in the sulfate-activating complex: combined continuum modeling and coarse-grained brownian

Yuhui Cheng1, Chia-En A Chang, Zeyun Yu

  • 1Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California, USA. ycheng@mcammon.ucsd.edu

Biophysical Journal
|August 12, 2008
PubMed
Summary

Enzymes use substrate channeling for sulfur metabolism efficiency. Simulations reveal electrostatics are crucial for channeling adenosine phosphosulfate (APS) between active sites, impacting biological processes.

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