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Free-Radical Chain Reaction and Polymerization of Alkenes02:35

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Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
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Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
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Published on: December 16, 2022

Biodegradable and radically polymerized elastomers with enhanced processing capabilities.

Jamie L Ifkovits1, Robert F Padera, Jason A Burdick

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Biomedical Materials (Bristol, England)
|August 12, 2008
PubMed
Summary
This summary is machine-generated.

Researchers developed acrylated poly(glycerol sebacate) (Acr-PGS), a biodegradable elastomer with tunable properties and enhanced processing for soft tissue engineering. This material offers improved fabrication options and controlled degradation for advanced biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Biodegradable elastomers are crucial for soft tissue engineering but often require high-temperature, vacuum processing, limiting scaffold fabrication.
  • Existing methods for creating complex scaffolds from biodegradable elastomers are constrained by processing limitations.

Purpose of the Study:

  • To develop a biodegradable elastomer with improved processing capabilities for soft tissue engineering applications.
  • To modify poly(glycerol sebacate) (PGS) with acrylates to enable controlled crosslinking and versatile fabrication methods.

Main Methods:

  • Acrylation of poly(glycerol sebacate) (PGS) precursors to create Acr-PGS macromers.
  • Free radical-initiated crosslinking (redox and photo-initiated) of Acr-PGS.
  • Mechanical property testing, in vitro/in vivo degradation and biocompatibility studies.
  • Electrospinning and photopolymerization to fabricate fibrous scaffolds using Acr-PGS and poly(ethylene oxide).

Main Results:

  • Acrylated-PGS (Acr-PGS) macromers allow for controlled crosslinking via free radical mechanisms.
  • Mechanical properties (Young's modulus, strain at break) were tunable based on molecular weight and % acrylation.
  • Acr-PGS demonstrated mild to moderate inflammatory response in vivo, typical for biodegradable polymers.
  • Fibrous scaffold morphology was controlled by component ratios in electrospinning.

Conclusions:

  • Acrylated-PGS offers enhanced processing and tunable properties for soft tissue engineering.
  • The developed system provides a versatile platform for creating complex biodegradable scaffolds.
  • This advancement supports improved approaches in engineering soft tissues.