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Bioactive and Injectable Granular Hydrogels Incorporating Decellularized Extracellular Matrix.

Daniela Trindade1,2,3,4, Nikolas Di Caprio5, Ana C Maurício2,6

  • 1Centre for Rapid and Sustainable Product Development (CDRSP), Polytechnic of Leiria, Marinha Grande 2030-028, Portugal.

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Summary
This summary is machine-generated.

Researchers developed injectable granular hydrogels combining bioactive decellularized extracellular matrices (dECMs) with hyaluronic acid. This novel biomaterial enhances mechanical stability and promotes cell adhesion for potential temporomandibular joint disc (TMJd) repair.

Keywords:
decellularized extracellular matrixgranular hydrogelshyaluronic acidinjectabletemporomandibular joint

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Decellularized extracellular matrices (dECMs) offer bioactive cues for tissue repair but lack mechanical strength.
  • Temporomandibular joint disc (TMJd) tissues have limited natural regenerative capacity.
  • Granular hydrogels offer injectable, mechanically stable microparticles for tissue repair.

Purpose of the Study:

  • To combine the bioactivity of dECM with the mechanical stability of norbornene hyaluronic acid (NorHA) granular hydrogels.
  • To create an injectable and bioactive biomaterial for TMJd repair.
  • To investigate the impact of dECM concentration on microgel properties and cell interaction.

Main Methods:

  • Encapsulation of dECM (0.4% and 0.8%) within NorHA microgels.
  • Formation of granular hydrogels with shear-thinning and self-healing properties.
  • Secondary cross-linking via visible light or interstitial dECM addition.
  • Assessment of microgel stiffness, ECM release, and fibrochondrocyte adhesion.

Main Results:

  • dECM incorporation increased microgel stiffness and supported sustained ECM release.
  • Granular hydrogels exhibited shear-thinning and self-healing capabilities.
  • Incorporated dECM supported fibrochondrocyte adhesion, creating an injectable and bioactive material.

Conclusions:

  • The developed dECM-NorHA granular hydrogels are injectable, bioactive, and mechanically tunable.
  • This system shows promise for enhancing the repair of fibrocartilaginous tissues like the TMJd.
  • The combination of dECM bioactivity and granular hydrogel mechanics offers a versatile platform for regenerative applications.