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Updated: Jul 2, 2026

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture
10:08

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture

Published on: October 21, 2009

Patterned melt electrospun substrates for tissue engineering.

Paul D Dalton1, Nanna T Joergensen, Juergen Groll

  • 1School of Biological Sciences, University of Southampton, Bassett Cr East, Southampton SO16 7PX, UK. dalton@dwi.rwth-aachen.de

Biomedical Materials (Bristol, England)
|August 12, 2008
PubMed
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This study demonstrates melt electrospinning of poly(ethylene glycol)-block-poly(epsilon-caprolactone) (PEG-b-PCL) and PCL blends to create patterned scaffolds. Optimized parameters enabled precise fiber deposition for potential tissue engineering applications.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Science

Background:

  • Patterning techniques are crucial for creating advanced tissue engineering scaffolds.
  • Electrospinning offers a versatile method for fabricating fibrous biomaterials.
  • Biodegradable polymers like PEG-b-PCL and PCL are promising for regenerative medicine.

Purpose of the Study:

  • To investigate the melt electrospinning of PEG-b-PCL and PCL blends for scaffold fabrication.
  • To determine optimal electrospinning parameters for controlled fiber deposition.
  • To assess the potential of patterned electrospun fibers for cell adhesion and tissue engineering.

Main Methods:

  • Melt electrospinning of PEG-b-PCL and PCL blends.
  • Optimization of electrospinning parameters including flow rate, voltage, and collection distance.

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Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications
12:28

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Published on: December 23, 2017

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Last Updated: Jul 2, 2026

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture
10:08

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture

Published on: October 21, 2009

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications
12:28

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Published on: December 23, 2017

  • Fabrication of aligned fibrous scaffolds using an x-y stage for precise patterning.
  • Evaluation of fiber diameter, deposition uniformity, and cell adhesion.

    • Main Results:

    • Optimal electrospinning parameters were identified, with collection distance between 3-5 cm yielding focused fiber deposition.
    • Aligned lines of electrospun fibers (200-400 microm width) were successfully deposited discretely and continuously.
    • Fibroblast cells showed preferential adhesion to the PCL-rich fiber regions, with poor adhesion to PEG.
    • Uniform fiber diameters (0.96 +/- 0.19 microm) were achieved.

    Conclusions:

    • Melt electrospinning of PEG-b-PCL/PCL blends can produce patterned scaffolds suitable for tissue engineering.
    • Precise control over fiber deposition using an x-y stage is achievable.
    • Surface modification to enhance hydrophilic fiber adhesion is recommended for improved in vitro performance.