Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Endocarditis I: Introduction

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...

Endocarditis III: Medical Management

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...

Endocarditis IV: Nursing Management

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Identifying distinct subgroups with severe pain in sickle cell disease: A cluster analysis of the GRNDaD multi-center registry.

PloS one·2025

Same author

Biopsychosocial Factors Associated With Pain and Pain-Related Outcomes in Adults and Children With Sickle Cell Disease: A Multivariable Analysis of the GRNDaD Multicenter Registry.

The journal of pain·2023

Same author

Cerebellitis associated with cryptococcal-immune reconstitution inflammatory syndrome.

IDCases·2023

Same author

Quality of life in a large multinational haemophilia B cohort (The B-Natural study) - Unmet needs remain.

Haemophilia : the official journal of the World Federation of Hemophilia·2022

Same author

Coinfection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Bordetella bronchiseptica Pneumonia in a Renal Transplant Patient.

Cureus·2021

Same author

Natural history study of factor IX deficiency with focus on treatment and complications (B-Natural).

Haemophilia : the official journal of the World Federation of Hemophilia·2020

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Abiotrophia spp. and Staphylococcus epidermidis endocarditis treated with daptomycin.

Eliahu Bishburg¹, Daman Ghuman, Alice Cohen

¹Division of Infectious Diseases, Newark Beth Israel Medical Center, Newark, NJ, USA. EBishburg@sbhcs.com

Thescientificworldjournal

|August 12, 2008

Summary

Abiotrophia species cause about 5% of endocarditis cases. A rare case of Staphylococcus epidermidis and Abiotrophia spp. endocarditis resistant to vancomycin successfully responded to daptomycin and rifampin treatment.

Related Experiment Videos

Last Updated: Jul 2, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Area of Science:

Infectious Diseases
Cardiology
Microbiology

Background:

Endocarditis is a serious infection affecting heart valves, with Abiotrophia species accounting for approximately 5% of cases.
Standard treatment regimens for Abiotrophia endocarditis typically involve penicillin with gentamicin or vancomycin.
Co-infections, such as with Staphylococcus epidermidis, can complicate treatment strategies.

Observation:

This report details a challenging case of infective endocarditis involving both Staphylococcus epidermidis (Coagulase-Negative Staphylococci) and Abiotrophia species.
The patient's endocarditis proved refractory to vancomycin, a commonly prescribed antibiotic for such infections.
This clinical scenario highlights the potential for antimicrobial resistance in complex endocarditis cases.

Findings:

The combined Staphylococcus epidermidis and Abiotrophia spp. endocarditis demonstrated a lack of therapeutic response to vancomycin.
Successful treatment was achieved using a combination of daptomycin and rifampin.
This suggests daptomycin and rifampin as a viable alternative therapeutic option for resistant cases.

Implications:

The findings suggest that vancomycin may not be effective for all cases of Abiotrophia and Staphylococcus epidermidis co-infection.
Daptomycin combined with rifampin presents a promising salvage therapy for refractory infective endocarditis caused by these organisms.
Further research into optimal treatment regimens for polymicrobial endocarditis is warranted to improve patient outcomes.