Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Does mechanical stimulation have any role in urinary bladder tissue engineering?

Walid A Farhat¹, Herman Yeger

¹Urology Division, Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada. Walid.farhat@sickkids.ca

World Journal of Urology

|August 12, 2008

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Social and Anxiety-Like Behaviors Are Affected in Juvenile Mice With Gli2<sup>+/-</sup> but Not Gli3<sup>+/𝛥699</sup> Genetic Modifications.

Brain and behavior·2026

Same author

A Comprehensive Oncological Biomarker Framework Guiding Precision Medicine.

Biomolecules·2025

Same author

A Rare Case of Ewing Sarcoma Presenting in the Adult Bladder-Treatments and Need for More Discussion.

Urology·2025

Same author

"Enhancing equitable impact: ethical, legal, and sustainable approaches in short-term surgical outreach for global child health".

Frontiers in pediatrics·2025

Same author

The use of alpha-adrenergic antagonists in pediatric nephrolithiasis: a systematic review.

Frontiers in pediatrics·2024

Same author

Cell-based assay to detect small molecules restoring levels of let-7 miRNAs.

American journal of cancer research·2024

Tissue engineering for urinary bladders benefits from mechanical stimulation. A novel bioreactor mimics bladder dynamics, promoting cell growth and extracellular matrix production for improved tissue function.

Area of Science:

Biomedical Engineering
Regenerative Medicine
Urology

Background:

Current urinary bladder tissue engineering uses biocompatible scaffolds with autologous cells.
In utero bladder development requires dynamic filling and emptying, suggesting in vitro models benefit from mechanical stimulation.
Mechanical stimulation promotes cell proliferation and extracellular matrix production, crucial for hollow dynamic organs.

Purpose of the Study:

To develop a tissue bioreactor that mimics in vivo urinary bladder dynamics.
To create a cellular environment facilitating cell-cell and cell-matrix interactions.
To engineer functional urinary bladder tissue in vitro.

Main Methods:

Devised tissue bioreactors to imitate the filling and emptying cycles of a normal bladder.

More Related Videos

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Published on: July 5, 2024

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Published on: August 18, 2014

Related Experiment Videos

Last Updated: Jul 2, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Published on: July 5, 2024

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Published on: August 18, 2014

Designed bioreactors to provide a controlled cellular environment.

Focused on recapitulating in vivo conditions for tissue development.

Main Results:

The bioreactor successfully mimics physiological conditions for bladder tissue engineering.
Facilitated cell-cell and cell-matrix interactions within the engineered tissue.
Demonstrated potential for improved tissue development through controlled mechanical stimulation.

Conclusions:

Validation of a urinary bladder tissue bioreactor is essential for controlled physiological studies.
This technology will interest researchers in urinary bladder physiology.
Advances in bioreactor design will aid urinary bladder tissue engineering.