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Published on: September 22, 2020
Single center experience with provisional abciximab therapy in complex lower limb interventions.
H Keo1, N Diehm, R Baumgartner
1Swiss Cardiovascular Center, Division of Angiology, Inselspital Bern, University Hospital and University of Bern, Switzerland.
VASA. Zeitschrift Fur Gefasskrankheiten
|August 12, 2008
Summary
Abciximab (glycoprotein IIb/IIIa antagonist) effectively reduces rethrombosis in complex lower limb peripheral catheter interventions. This therapy shows significant clinical and hemodynamic improvements, making it a valuable adjunct for complex interventions.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Vascular Surgery
Background:
- Glycoprotein IIb/IIIa antagonists like abciximab improve outcomes in femoro-popliteal interventions.
- Limited data exists on abciximab use in complex lower limb peripheral catheter interventions.
- This study evaluates abciximab in complex peripheral interventions with high rethrombosis risk.
Purpose of the Study:
- To assess the clinical and hemodynamic outcomes of provisional abciximab therapy.
- To determine the efficacy of abciximab in complex peripheral catheter interventions.
- To evaluate its role in preventing early rethrombosis.
Main Methods:
- Retrospective analysis of 44 patients undergoing complex peripheral catheter interventions.
- Provisional abciximab administered due to imminent risk of rethrombosis (e.g., prolonged intervention, compromised flow, distal embolization, thrombus evolution).
- Standard abciximab dosing (0.25 mg/kg bolus, 0.125 mcg/kg/min infusion for 12 hours) and prospective outcome assessment.
Main Results:
- Technical success rate was 95% with significant ABI improvement (0.5 to 0.88, p < 0.001).
- Immediate hemodynamic improvement in 91% of patients.
- Sustained clinical improvement at 6 months was 66%, with best outcomes in iliac and below-knee segments.
Conclusions:
- Abciximab serves as a crucial adjunct in managing complex peripheral catheter interventions.
- It effectively prevents imminent rethrombosis in high-risk patients.
- Consider abciximab for complex lower limb interventions to improve patient outcomes.
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