Related Experiment Video
Updated: Jul 2, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
New drugs in acute myeloid leukemia
1Clinical Research Division Fred Hutchinson Cancer Research Center and Department of Hematology, University of Washington Medical Center, Seattle, WA 98109, USA. eestey@comcast.net <eestey@comcast.net>
Abstract:
Standard treatment of acute myeloid leukemia (AML) results in a median survival of approximately 1 year. Together with increasing understanding of the biology of AML, this has led to the introduction of many new anti-AML drugs. Here we discuss the most prominent of these: clofarabine, epigenetic-acting agents, gemtuzumab ozogamycin, and FLT3 inhibitors. All are indubitably active. However, their therapeutic efficacy relative to each other and to standard therapy is unclear. The future is likely to see combinations of the drugs with each other and with more standard therapies. There also will be a shift away from inquiring which therapy is best for the average patient to inquiring which therapy is best for a given patient with a specific constellation of disease markers.
Related Concept Videos
Drugs that Destabilize Microtubules
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistent Cancers
FDA Approved Drugs: Changes to Approved Drugs
Treatment Resistant Cancers