Peptide identification in whole-sample mass spectrometry proteomics
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Updated: Jul 2, 2026

A Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Platform for Investigating Peptide Biosynthetic Enzymes
Published on: May 4, 2020
Richard Pelikan1, Milos Hauskrecht
1Intelligent Systems Program, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract:
Peptide identification for whole-sample mass spectrometry (MS) proteomics is in its infancy. While sophisticated tandem MS/MS instrumentation exists for accurate peptide identification after sample separation, there are few options for those who produce data from intact protein samples. We present a novel algorithm which uses available information from the literature and online protein databases to provide reliable labeling of features in whole-sample MS proteomic data.
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