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Natural products as inhibitors of carcinogenesis

Jacquelyn M Guilford1, John M Pezzuto

  • 1University of Hawaii at Hilo, College of Pharmacy, 34 Rainbow Drive, Hilo, Hawaii 96720, USA.

Expert Opinion on Investigational Drugs
|August 13, 2008
PubMed
Abstract

Insights

Natural products show great potential for cancer prevention. These compounds can inhibit carcinogenesis and may significantly reduce cancer incidence and mortality rates.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Cancer incidence and mortality rates remain high despite extensive research.
  • Primary prevention is the most effective strategy for cancer reduction.
  • Cancer chemoprevention offers a logical approach for high-risk individuals.

Purpose of the Study:

  • This review focuses on natural products as inhibitors of carcinogenesis.
  • To explore the role of natural products in cancer chemoprevention.

Main Methods:

  • Review of scientific literature on natural products and cancer chemoprevention.
  • Analysis of studies demonstrating the efficacy of natural products in inhibiting carcinogenesis.

Main Results:

  • Natural products are biologically active agents that can prevent and reverse cancer development.
  • Derivatives of natural compounds have shown promise in clinical trials.

Conclusions:

  • Natural products hold significant potential for cancer prophylaxis.
  • Further development is needed to integrate natural product chemoprevention into standard medical practice.
  • These agents offer a promising avenue for reducing cancer morbidity and mortality.

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