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Labeling index in squamous cell carcinoma of the larynx
M Balzi1, B M Ninu, A Becciolini
1Radiation Biology Laboratory, Clinical Physiopathology Department, University of Florence, Italy.
Abstract:
Two cell kinetic parameters, the 3H-thymidine labeling index (TLI) and the mitotic index (MI), were studied in vitro on fragments of squamous cell carcinoma tissue of the larynx. They were evaluated to identify those elements able to characterize the growth of these solid tumors. The values of these parameters were analyzed as a function of the clinical stage and the involvement of the regional lymph nodes. Results showed a statistically significant increase in the TLI from stage T1 to T3. No statistically significant differences in the TLI values were observed between the patients with positive and negative lymph nodes.