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Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
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[2- and 4-phenylethynylpyrenes--new fluorescent labels for DNA]

I V Astakhova, V A Korshun

    Bioorganicheskaia Khimiia
    |August 13, 2008
    PubMed

    Abstract:

    It was shown by the example of 1-, 2-, and 4-phenylethynylpyrene 2'-arabino-carbamate derivatives of uridine that the position of pyrene substitution substantially affects the spectral and photophysical properties of the fluorophore and its ability to interact with the nucleic base.

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