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Antibiotics from Extremophilic Micromycetes.

A A Baranova1, V A Alferova1,2, V A Korshun1,3,2

  • 1Gause Institute of New Antibiotics, 119021 Moscow, Russia.

Russian Journal of Bioorganic Chemistry
|January 4, 2021
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Extremophilic micromycetes are a promising source of novel antibiotic compounds. Recent studies highlight their potential to combat antibiotic-resistant pathogens, offering new solutions for medicine and agriculture.

Keywords:
antibioticsbiotechnologyextreme habitatsextremophilesmicromycetesresistance

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Area of Science:

  • Microbiology
  • Natural Product Chemistry
  • Biotechnology

Background:

  • Extremophilic microorganisms thrive in extreme environments.
  • Their enzymes (extremozymes) have industrial applications.
  • The potential of extremophiles as sources of novel bioactive compounds remains largely untapped.

Purpose of the Study:

  • To review recent findings on antibiotic compounds from extremophilic micromycetes.
  • To classify these metabolites by structure and biosynthetic origin.
  • To summarize their biological activities.

Main Methods:

  • Literature review of studies published in 2018-2019.
  • Classification of secondary metabolites based on chemical structure.
  • Analysis of biosynthetic pathways.
  • Compilation of data on biological activities.

Main Results:

  • Extremophilic micromycetes produce diverse secondary metabolites with antibiotic properties.
  • These compounds exhibit potential against antibiotic-resistant pathogens.
  • Novel structural scaffolds and mechanisms of action are being discovered.

Conclusions:

  • Extremophilic micromycetes represent a valuable resource for discovering new antibiotics.
  • Further research can yield compounds to address the global challenge of antimicrobial resistance.
  • These findings support the exploration of extreme environments for drug discovery.