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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Structure-Activity Relationships and Drug Design01:28

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Prodrugs01:30

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
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Principles of Drug Action01:24

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Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
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Targets for Drug Action: Overview01:26

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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Drug Repurposing: An Effective Tool in Modern Drug Discovery.

V S Kulkarni1, V Alagarsamy1, V R Solomon1

  • 1MNR College of Pharmacy, MNR Nagar, Fasalwadi, Sangareddy, Hyderabad 502294 India.

Russian Journal of Bioorganic Chemistry
|February 28, 2023
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Drug repurposing accelerates finding new treatments by identifying existing drugs for novel indications. This strategy is crucial for faster drug discovery and addressing urgent healthcare needs, especially during pandemics.

Keywords:
clinical trialsdrug discoverydrug repurposingmolecular dockingpost-market safety

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Area of Science:

  • Pharmacology and Drug Discovery
  • Computational Biology and Bioinformatics

Background:

  • Drug repurposing, using existing medications for new therapeutic uses, has gained significant traction, particularly during the COVID-19 pandemic.
  • The urgent need for rapid therapeutic solutions highlights drug repurposing as a vital strategy to expedite the drug discovery pipeline and alleviate healthcare system burdens.

Purpose of the Study:

  • To outline the strategic methodologies employed in drug repurposing.
  • To compile a list of drugs that have been successfully repurposed and their respective new indications.

Main Methods:

  • Drug repurposing involves a multi-step process: drug identification, preclinical efficacy evaluation, and progression to Phase II clinical trials.
  • Drug candidates are identified through computational and experimental approaches, leveraging public drug databases and diverse data sources including research, clinical trials, and off-label use reports.
  • Advanced bioinformatics tools, artificial intelligence algorithms, and integrated analyses (genetics, clinical data, molecular docking, pathways, phenotypes) are utilized to optimize target-drug interaction identification.

Main Results:

  • The study details various strategies for systematic drug repurposing.
  • A compilation of repurposed drugs and their newly identified indications is presented.

Conclusions:

  • Drug repurposing offers an efficient pathway to accelerate the development of new treatments.
  • The integration of diverse data sources and advanced computational tools enhances the success rate of identifying viable drug candidates for repurposing.