Edwards syndrome with double trisomy
J Tennakoon1, Y Kandasamy, G Alcock
1Neonatal Intensive Care Unit, The Townsville Hospital, Douglas, QLD 4814, Australia.
Abstract:
Double trisomy is rare and the only case reported in the literature died soon after birth. We present another case of double trisomy (48XYY, +18) in a male neonate, who was born to a 28-year-old gravida three parity one mother at 35 weeks of gestation. The baby had features of trisomy 18. Karyotype of the patient showed 48, XYY, +18, Ish (DYZ3*2), (D18Z1*3), nuc ish (DYZ3*2), (D18Z1*3) . The patient had clinical features of trisomy 18. There was no family history of diabetes mellitus and no exposure to chemicals. It has been suggested that the rarity of Y-chromosome involvement in trisomy 18 may be due to discrepancy between the sexes.
Related Concept Videos
Meiosis I
Nondisjunction
Nondisjunction
Nondisjunction
Karyotyping
Karyotyping


