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Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

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Retinal microvascular plasticity in a premature neonate.

Y Kandasamy¹, L Hartley², R Smith³

¹1Department of Neonatology,The Townsville Hospital,Townsville, QLD,Australia.

Journal of Developmental Origins of Health and Disease

|February 1, 2017

Summary

Retinopathy of prematurity (ROP) involves abnormal retinal vessel changes. A case study shows intravitreal VEGF antagonists temporarily improved ROP but vessel tortuosity recurred, indicating retinal plasticity.

Keywords:

neonate plasticity premature preterm retinal microvascular

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Last Updated: Mar 8, 2026

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Area of Science:

Ophthalmology
Neonatology
Vascular Biology

Background:

Retinopathy of prematurity (ROP) is a leading cause of blindness in premature infants.
Abnormal retinal vessel dilation and tortuosity characterize severe ROP.
Vascular endothelial growth factor (VEGF) signaling pathways are implicated in ROP pathogenesis.

Observation:

A premature infant (24 weeks gestation, 640 g) developed severe ROP.
Intravitreal bevacizumab (VEGF antagonist) initially reduced retinal vessel tortuosity and dilation.
Vessel abnormalities re-emerged four weeks after treatment.

Findings:

The case demonstrates the dynamic nature of retinal microvascular changes in premature neonates.
Retinal microvascular plasticity may influence treatment response in ROP.
VEGF antagonists offer temporary benefits but do not permanently resolve ROP-related vascular changes.

Implications:

Understanding retinal plasticity is crucial for managing ROP.
Further research into long-term effects and alternative treatments for ROP is warranted.
Advances in neonatal care and retinal imaging enable closer observation of ROP progression and vascular dynamics.