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Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage
Published on: February 15, 2020
Could oxidative stress associate with age products in cataractogenesis?
Anjuman Gul1, M Ataur Rahman, Syed Nazurl Hasnain
1Department of Biochemistry, Ziauddin University, Shahrah-e-Ghalib, Clifton, Karachi, Pakistan. anjummurtaza@hotmail.com
Current Eye Research
|August 13, 2008
Summary
Advanced glycation end products (AGEs) correlate with oxidative stress markers like malondialdehyde and vitamin E in elderly cataract patients. Increased AGEs, a result of oxidative stress, may play a role in cataract formation, especially in diabetic individuals.
Area of Science:
- Ophthalmology
- Gerontology
- Endocrinology
Background:
- Oxidative stress is implicated in aging and lens cataract formation.
- Investigating the link between oxidative stress and advanced glycation end products (AGEs) in elderly individuals with and without diabetes and cataract is crucial.
Purpose of the Study:
- To determine the association between oxidative stress and AGEs in elderly diabetic and non-diabetic patients with cataract.
- To explore the role of AGEs and oxidative stress markers in cataractogenesis.
Main Methods:
- The study involved 156 subjects, including normal elderly, elderly diabetics (with/without cataract), and elderly non-diabetics with cataract.
- Key markers assessed included malondialdehyde, vitamin E, serum AGEs, fasting blood glucose, HbA1c, and serum fructosamine.
- Participants were recruited from the Eye Ward, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
Main Results:
- Significant positive correlation found between serum AGEs and malondialdehyde in elderly cataract patients (diabetic and non-diabetic).
- Significant negative correlation observed between serum AGEs and vitamin E in the same groups.
- Elevated malondialdehyde and serum AGEs were noted in elderly cataract patients compared to controls, while vitamin E was decreased. Diabetic patients showed significantly higher glycemic control markers.
Conclusions:
- Increased AGEs are associated with oxidative stress in elderly populations.
- AGEs, potentially arising from oxidative stress, may contribute to cataract formation.
- Cataract development appears more rapid in diabetic patients due to these factors.
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