Related Experiment Video
Updated: Jul 2, 2026
11:56
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
Published on: September 28, 2017
Night-time work predisposes to non-Hodgkin lymphoma
Tuuli A Lahti1, Timo Partonen, Pentti Kyyrönen
1Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland.
International Journal of Cancer
|August 13, 2008
Summary
Night-time shift work significantly increases the risk of non-Hodgkin lymphoma (NHL) in men. This study found night shift workers have a greater risk of developing NHL compared to the general population.
Area of Science:
- Occupational Health
- Epidemiology
- Oncology
Background:
- Non-Hodgkin lymphoma (NHL) is a significant public health concern.
- The potential impact of occupational exposures, such as night-time shift work, on NHL risk requires further investigation.
Purpose of the Study:
- To determine if night-time shift work is associated with a higher incidence of non-Hodgkin lymphoma (NHL).
Main Methods:
- Utilized the Finnish job-exposure matrix (FINJEM) to estimate night-time work exposure.
- Analyzed a large cohort (1,669,272 individuals) born between 1906-1945, tracking NHL cases from 1971-1995.
- Calculated observed vs. expected cancer cases and cumulative night-time work exposure scores.
Main Results:
- A significant increase in NHL risk was observed in men engaged in night-time shift work (p = 0.01).
- The overall relative risk for NHL in male night-time workers was 1.10 (95% CI: 1.03-1.19).
- Men with high cumulative night-time work exposure showed a risk ratio of 1.28 (95% CI: 1.03-1.59) after a 10-year lag period.
Conclusions:
- Night-time shift work is a significant risk factor for developing non-Hodgkin lymphoma in men.
- Individuals with prolonged and high levels of night-time work exposure face an elevated risk of NHL.
- Findings suggest night-time workers are a population group with increased cancer proneness, specifically for NHL.
Related Concept Videos
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...