Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 2, 2026

Pore-scale Imaging and Characterization of Hydrocarbon Reservoir Rock Wettability at Subsurface Conditions Using X-ray Microtomography
12:18

Pore-scale Imaging and Characterization of Hydrocarbon Reservoir Rock Wettability at Subsurface Conditions Using X-ray Microtomography

Published on: October 21, 2018

Quantitative accuracy of PET/CT for image-based kinetic analysis.

Youngho Seo1, Boon-Keng Teo, Mohiuddin Hadi

  • 1Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143-0946, USA. youngho.seo@radiology.ucsf.edu

Medical Physics
|August 14, 2008
PubMed
Summary

List-mode PET acquisition provides accurate quantification of activity concentrations, essential for dynamic PET imaging analysis. Reformatting list-mode data into different frames maintains this accuracy within specific activity limits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of a Thermostable Nigerose Phosphorylase for the Efficient Chemoenzymatic Radiosynthesis of a <i>S. aureus</i>-Targeted <sup>18</sup>F-Disaccharide.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Evaluation of radiation damage effects of low-energy Auger and conversion electrons emitted by <sup>134</sup>Ce decay using a Monte Carlo method.

Scientific reports·2026
Same author

Tumor response and tolerability under fractionated x-ray irradiation in a mouse xenograft model.

Physics in medicine and biology·2026
Same author

A Prodrug Strategy to Conditionally Trap Therapeutic Payloads for Improved Tumor Retention.

ACS central science·2026
Same author

Pair production tomography enables imaging of MeV-scale gamma-emitting theranostic radionuclides.

Research square·2026
Same author

Pre-clinical SPECT and SPECT-CT in Oncology.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Accurate quantification of activity concentrations (e.g., Bq/ml) is crucial for compartment modeling and kinetic analysis of dynamic Positron Emission Tomography (PET) images.
  • Dynamic PET data acquired in list-mode offer flexibility for reformatting into various dynamic image sequences post-acquisition, unlike static frame acquisitions.

Purpose of the Study:

  • To evaluate the quantitative accuracy of list-mode PET acquisitions using a Siemens Biograph 16 PET/CT scanner.
  • To assess the impact of different phantom configurations and data reformatting on quantitative accuracy.

Main Methods:

  • An anthropomorphic phantom filled with 18F-fluorodeoxyglucose (FDG) was used for PET data acquisition.
  • Three configurations were tested: simulated high initial concentration, static frames with list-mode reformatting, and list-mode with variable frame durations.

More Related Videos

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
09:00

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Published on: August 18, 2016

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
07:07

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

Related Experiment Videos

Last Updated: Jul 2, 2026

Pore-scale Imaging and Characterization of Hydrocarbon Reservoir Rock Wettability at Subsurface Conditions Using X-ray Microtomography
12:18

Pore-scale Imaging and Characterization of Hydrocarbon Reservoir Rock Wettability at Subsurface Conditions Using X-ray Microtomography

Published on: October 21, 2018

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
09:00

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Published on: August 18, 2016

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
07:07

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

  • Quantitative accuracy was compared against static images and known activity concentrations.

    • Main Results:

    • List-mode acquisition provides accurate quantification of activity concentrations within a clinically realistic range.
    • Count rate limitations are minimal for activities up to 370-440 MBq within the axial field of view.
    • Reformatting list-mode data into different frame durations preserves quantitative accuracy.

    Conclusions:

    • List-mode PET data acquired with the Siemens Biograph 16 PET/CT system are quantitatively accurate for image-based kinetic analysis.
    • The flexibility of list-mode acquisition and reformatting supports reliable quantitative analysis in PET studies.
    • Quantitative accuracy is maintained under specific activity concentration and system constraints.