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Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy
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Published on: April 27, 2021

A molecular noise generator.

Ting Lu1, Michael Ferry, Ron Weiss

  • 1Department of Electrical Engineering, Princeton University, J-319 E-quad, Princeton, NJ 08544-5263, USA.

Physical Biology
|August 14, 2008
PubMed
Summary
This summary is machine-generated.

Scientists developed a molecular noise generator to precisely control gene expression variations. This tool allows flexible modulation of gene expression noise, aiding evolutionary studies and genetic circuit analysis.

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Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
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Last Updated: Jul 2, 2026

Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy
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Published on: April 27, 2021

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

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Published on: May 9, 2011

Area of Science:

  • Synthetic Biology
  • Molecular Biology
  • Systems Biology

Background:

  • Intracellular gene expression noise is crucial for cellular function, development, and evolution.
  • Understanding and manipulating gene expression noise is challenging due to intrinsic cellular processes.

Purpose of the Study:

  • To design and present molecular noise generators for flexible modulation of gene expression noise.
  • To enable independent tuning of mean and variability of output proteins.
  • To explore the impact of input signal variability on noise generation.

Main Methods:

  • Developed two designs for a molecular noise generator.
  • Utilized a dual-signal mechanism for independent transcription and translation control.
  • Incorporated DNA copy-number regulation for expanded tuning spectrum.
  • Introduced input signal variability to assess control process-induced noise.

Main Results:

  • Achieved flexible modulation of gene expression noise profiles.
  • Demonstrated independent tuning of output protein mean and variability.
  • Expanded the tuning spectrum through DNA copy-number regulation.
  • Quantified noise induced by the control process under variable input conditions.

Conclusions:

  • The molecular noise generator offers precise control over gene expression variability.
  • This tool can be applied to study the robust or fragile properties of genetic circuits.
  • Facilitates research into the beneficial roles of gene expression noise in evolution and diversification.