Prognostic value of Holter monitoring in congestive heart failure
Iwona Cygankiewicz1, Wojciech Zareba, Antoni Bayes de Luna
1Department of Electrocardiology, Sterling Memorial University Hospital, Łódź, Poland. iwona.cygankiewicz@heart.rochester.edu
Insights
Dynamic electrocardiogram (ECG) markers from Holter monitoring, including heart rate variability and turbulence, can predict mortality in congestive heart failure (CHF) patients. Combining ECG data with imaging improves risk stratification for this widespread disease.
Area of Science:
- Cardiology
- Medical Technology
Background:
- Congestive heart failure (CHF) presents a significant and growing global health challenge with high mortality rates.
- Current treatments for CHF have limitations, making accurate risk stratification crucial for patient management.
Purpose of the Study:
- To review the prognostic value of Holter-derived ECG parameters in predicting mortality and modes of death in CHF patients.
- To emphasize the role of dynamic ECG markers in assessing myocardial vulnerability and autonomic function.
Main Methods:
- Literature review of studies utilizing ambulatory Holter monitoring in CHF patients.
- Analysis of various ECG parameters, focusing on dynamic markers like heart rate variability and turbulence.
- Consideration of combining ECG findings with myocardial substrate assessment.
Main Results:
- Holter-based ECG parameters, particularly dynamic markers, are independent predictors of total mortality and heart failure progression.
- Dynamic markers reflect myocardial vulnerability and autonomic nervous system activity, complementing imaging techniques.
- Combined ECG and substrate assessment offers a comprehensive view of mortality risk factors.
Conclusions:
- Dynamic Holter-derived ECG markers provide valuable prognostic information in CHF.
- Integrating ECG-based risk stratification with myocardial substrate assessment can enhance the understanding of mortality predictors in CHF.
Abstract:
Congestive heart failure (CHF) is an increasingly widespread, costly and deadly disease, frequently named as epidemics of the 21 century. Despite advancement in modern treatment, mortality rate in CHF patients remains high. Therefore, risk stratification in patients with CHF remains one of the major challenges of contemporary cardiology. Electrocardiographic parameters based on ambulatory Holter monitoring have been documented to be independent risk predictors of total mortality and progression of heart failure. Recent years brought an increased interest in evaluation of dynamic Holter-derived ECG markers reflecting changes in heart rate and ventricular repolarization behavior. It is widely accepted that structural changes reflecting myocardial substrate are better identified by means of imaging techniques, Holter monitoring on the other hand provides complementary information on myocardial vulnerability and autonomic nervous system. Therefore, combining the electrocardiographic stratification with assessment of myocardial substrate may provide the complex insight into interplay between factors contributing to death. The present article reviews the literature data on the prognostic role of various Holter-based ECG parameters, with special emphasis to dynamic ECG risk markers--heart rate variability, heart rate turbulence, repolarization dynamics and variability--in predicting mortality, as well as different modes of death in patients with CHF.
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