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Updated: Jul 2, 2026

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry
Published on: September 5, 2014
Use of variable p(H) interface to a mass spectrometer for the measurement of dissolved volatile compounds
1Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Abstract:
A wide variety of dissolved chemicals can be measured continuously with some specificity by directly interfacing a relatively inexpensive mass spectrometer to a solution. Specifically, we describe the construction and initial use of a membrane interace to a mass spectrometer which allows the continuous measurement of the concentration of dissolved volatile compounds in buffered aqueous solution. In addition to volatile compounds that do not dissociate appreciably at p(H) 7 (e.g., ethanol, ethylene glycol), volatile acids and bases, such as acetic acid or ammonia, can be measured with the interface is operated within the range 1=p(H)=12. We also discuss the sensitivity of the system to variations in flow rate and describe a satisfactory method for providing sufficiently constant flow rates.
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