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Updated: Jul 2, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
Published on: September 13, 2013
Highly functionalized 7-azaindoles as selective PPAR gamma modulators
Sheryl D Debenham1, Audrey Chan, Fiona Waiyu Lau
1Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.
Abstract:
A series of highly functionalized 3-aroyl and 3-phenoxy-2-methyl-7-azaindoles have been identified, which are potent selective PPARgamma modulators (SPPARgammaMs). Addition of substituents at the 6-position of the 7-azaindoles improves in vitro potency and pharmacokinetics. 7-Azaindoles have significantly improved off-target profiles compared to the parent indole series.
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